First NameBettina
Last NameMeissburger
Emailb.meissburger@dkfz.de
Supervisor NameABC
University Universität Stuttgart
CountryGermany
KeywordsMolecular mechanisms of adipogenesis in obesity and the metabolic syndrome
Publication Date11 October, 2015
DegreePhD
DomainBiology

Molecular mechanisms of adipogenesis in obesity and the metabolic syndrome

Abstract

Adipose tissue is a key player in whole body metabolism and excess adipose tissue poses a major risk factor for the development of metabolic disorders such as type 2 diabetes. In response to nutritional overload, de novo adipocyte differentiation can serve as an adaptive mechanism by increasing the storage capacity of adipose tissue andmaintaining normal adipocyte function. This in turn prevents systemic lipidoverload, which is a major cause for insulin resistance.

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